| spl | Fusion Exported Spline Data |
| LISREL 8 SIMPLIS Syntax Data |
| Vim Spelling Data |
| Windows Spool Data |
| WinView/400 Report Data |
| spl7 | Abacom sPlan 7 Circuit Diagram |
| splan | SPSS Statistics Simulation Plan |
| splf | SecureZIP Spool File |
| splsm | SmartPLS Model Data |
| splt | yDecode Split Data |
| spm | Corel WordPerfect Internal Data |
| Nanoeducator File |
| spmm | Spartan Molecular Mechanics Data |
| spmo | SpeedView Meta Object |
| spmsk | Substance Painter Smart Mask Data |
| spn | Corel WordPerfect Distribution Definition |
| GSSHA Storm Pipe Network |
| PC-SPAN SPAN Data |
| spo | SPOCK External Objects Data |
| SPSS Statistical Output |
| spom | FEARLUS Stochastic Patch Occupancy Model |
| spool | Ubisoft Game Launcher Spool Data |
| spop | InterTrust SPOP Data |
| spp | Scrapbook Factory Data |
| SPSS Windows Production Mode Data |
| sppr | Substance Painter Presets Data |
| spq | SPSS Saved ODBC Query |
| spr | ArchiCAD Slab Properties |
| ConQuest Exported Spreadsheet |
| NeroMIX SPR Data |
| Sega Dreamcast VR Sprite Data |
| SoftMax Pro 6 Protocol Data |
| spreporter | Mac OS X System Profiler Reporter Data |
| sprf | Manip Saved Proof File |
| sprx | SoftMax Pro GxP 6 Protocol Data |
| sps | Oracle Package Specification |
| Sharkport Saved Game |
| SPSS Syntax File |
| SyncBack Exported Profile |
| spsd | eXtendable Wad Editor SPSD Data |
| spsm | Substance Painter Smart Material Data |
| spsx | SPSS Password Protected Data |
| spt | EGSEING Spectrum Mode Data |
| SpeedTree Tree Data |
| spub | BeLight Disc Cover Data |
| spud | iGO Primo SpeedCam Database Update |
| spumux | DVDAuthor XML Subtitle Data |
| spv | Spekwin32 Data |
| SPSS Output Document |
| spvchain | MultiBit Locally Stored Blockchain |
| spwb | ShadowProtect Write Buffer Data |
| spx | Mac OS X System Profiler XML Report |
| sq3 | oml2-server Database |
| SQLite 3 Database |
| sq7 | Daktronics Venus 7000 Sequence Data |
| sqb | SQL Backup SQL Server Backup |
| sqd | DNASTAR SeqMan Document |
| FidoNet Squish Data |
| Sysquake SQ Data |
| sqdb | SpellQuizzer Database |
| sqexp | SpellQuizzer Exported Data |
| sqf | Sothink SWF Quicker File |
| sqg | SeQuence Graph Data |
| sqi | FidoNet Squish Index Data |
| sql | FidoNet Squish Lastread Storage |
| SQL Script |
| sqlaudit | Microsoft SQL Server Audit Log |
| sqlite | SQLite Database |
| WhatsApp Messenger for iPhone Database |
| sqlite-shm | SQLite 3 Shared Memory Data |
| SQLite Shared Memory Data |
| sqlite-wal | SQLite Quasi-persistent Data |
| sqlite2 | SQLite 2.0 Database |
| sqlite3 | SQLite 3 Database |
| sqlite3-shm | SQLite 3 Shared Memory Data |
| sqlitedb | SQLite Database |
| sqlitedb-shm | SQLite Shared Memory Data |
| sqlitedb-wal | SQLite Quasi-persistent Data |
| sqlplan | Microsoft SQL Server Database Plan |
| sqlt | SQLite Database |
