| ene | GROMACS Binary Energy File |
| enex | EverNote XML Archive |
| enf | EndNote Filter Data |
| enh | CRiSP Harvest Model Enhancement File |
| enk | Sybase Enterprise Portal Security Key |
| enl | EndNote Library Data |
| enlx | EndNote X Compressed Library Data |
| eno | FruitfulTime TaskManager Encrpted Notes |
| enp | EndNote Preferences |
| enq | EndNote Saved Search |
| enr | EnRoute v2 Toolpath Data |
| enref | EverNote Food Data |
| ens | EndNote Style |
| enw | EndNote Import Data |
| enz | EndNote Connection Data |
| eo1 | MPE+ EO1 Data |
| eoc | EncryptOnClick Encrypted File |
| eoff | Exocad 3D Library |
| eom | EON Studio Mobile Prototype Library |
| eon | Strange Eons Data |
| eop | EON Studio Prototype Library |
| ep | ElmerPost Data File |
| epb | EP Budgeting Data File |
| epc | EXPACS-V Document |
| epd | Extended Position Description File |
| epf | Microsoft Exchange Security Settings |
| epg | DynaVox Page File |
| eph | SiRFDemo GPS Ephemeris File |
| epim | EssentialPIM Database |
| epitask | Telestream Episode Task |
