| sac | Single Assignment C Code |
| sal | Gupta Scalable Application Language File |
| sap | Stadium Application |
| sapz | Stadium Archive |
| saq | SAS 6 Sequential Engine Access Descriptor Data |
| sas | SAS Program |
| sas7bpgm | SAS Stored Program |
| sas7bput | SAS Permanent Utility |
| sas7butl | SAS Utility |
| sass | Sass Indented Syntax Data |
| sb | Laird smartBASIC Source Code |
| sbr | Visual Studio Source Browser Data |
| sbsx | Microsoft Storyboard Shapes File |
| sbt | SBT Build Definition |
| sc | Esterel Unsorted Circuit Code |
| sca | Scala InfoChannel Script |
| scala | Scala Source Code |
| scat | RealView Scatter-loading Data |
| scb | Scala InfoChannel Published Script |
| scc | Microsoft Visual SourceSafe File |
| sce | Scilab Script |
| scenesettings | Amazon Lumberyard FBX Rules Data |
| scex | Modgen Scenarion Data |
| sci | Scilab Macro Definitions |
| scm | Scheme Source Code |
| scn | Godot Engine Binary Scene Data |
| scpp | TestComplete C++Script Unit |
| scpt | AppleScript Script |
| scptd | AppleScript Script Bundle |
| scq | SAS 6 Catalog Data |