| sig | Powersim Studio Simulation Game |
| sign | GNU Privacy Guard Signature Data |
| signature | e-Filing Signature Data |
| sik | Microsoft Word Backup Data |
| silk | Symbolic Link Spreadsheet |
| silo | MeshTV Data |
| sim | CARE-S InfoWorks Simulation Parameters Data |
| sim | ESI ITI SimulationX Model |
| sim | Simile Model |
| sim | Steam Game Backup Metadata |
| simfreq | PLINK Simulation Parameter Data |
| simmodel | Altium Designer Simulation Model |
| simodel | Altium Designer Signal Integrity Model |
| sin | WRAP SALT Input Data |
| sin | Xperia X10 Phone SIN Firmware |
| sip | Powersim Studio Model |
| siq | Tektronics RSA306 IQ Streaming Data |
| siqd | Tektronics RSA306 SIQ Data |
| siqh | Tektronics RSA306 SIQ Header |
| sir | Powersim Studio Simulation Run File |
| sis | Steam Game Backup Info |
| sit | Epson Projector Basic Scenario Data |
| sit | PTC Creo Site Parameter Data |
| site | Sitescooper Sites Data |
| sitf | Seanau Icon Toolkit Data |
| sitl | StuffIt Library Data |
| sito | Stuffit Translator Data |
| sitv | StuffIt Viewer Data |
| siw | ANSYS SIwave Data |
| sj | Google Science Journal Data |
