| sad | Windows Server Security Association Database |
| sae | Sage Accountant Link |
| safe | WebMoney Keeper CLASSIC Purse Backup |
| safetext | SafeText Data |
| saff | SuperStream Alternative File Format Data |
| sah | SETI@home Data |
| sai | Burrows-Wheeler Alignment Tool SAI Data |
| saj | Sage 50 Folder Data |
| sal | WRAP Salinity Simulation Results Data |
| sam | PaleoMag ASCII Sample Data |
| sam07 | SAM 2007 Package |
| samp | Apache Drill Sample Data |
| sapssd | SAP GUI Data |
| sar | Sibelius Arrange Style |
| sas7bacs | SAS Access Descriptor |
| sas7baud | SAS Audit Data |
| sas7bbak | SAS Backup |
| sas7bcat | SAS Catalog |
| sas7bdat | SAS Data Set |
| sas7bdmd | SAS Data Mining Database |
| sas7bfdb | SAS Consolidation Database |
| sas7bitm | SAS Item Storage |
| sas7bmdb | SAS Multi-dimensional Database |
| sas7bndx | SAS Index |
| sas7bvew | SAS View |
| sas7bvew | SAS Stat Studio Metadata |
| sasf | NASA Spacecraft Activity Sequence File |
| sat | Standard ACIS Text |
| sav | General Saved Data |
| sav | Parallels Desktop Saved State Image |