| sp | SignPlot Document |
| sp | STK Sensor Pointing File |
| sp3 | NGS Standard Product 3 Format Data |
| spa | MikuMikuDance Sphere Mapping File |
| spa | Nicolet OMNIC Data |
| spbm | VMware vSphere Storage Policy Based Management Data |
| spc | SVAL Spectrogram Data |
| spc | Thermo Scientific SPC File |
| spc | Microsoft Software Publisher Certificate |
| spc | Galactic SPC Data |
| spcmd | Stereoscopic Player Commands Data |
| spcolor | Microsoft SharePoint Color Palette Data |
| spd | SPSD/M Database |
| spd | Form Z Suspended Rendering FIle |
| spd | Windows Server Security Policy Database |
| spd | SpecTRM Specification |
| spda | Surveyor PDA Detector Data |
| spdata | Microsoft SharePoint Project Data |
| spdb | iGO Primo SpeedCam Database |
| spdc | SAS SPD Data Set |
| spdnv | Spreadtrum NV Backup |
| spe | SPSS Extension |
| speccy | Speccy Snapshot Data |
| spef | Standard Parasitic Exchange Format |
| spentry | Spartan Entry Database |
| spex | SPEX Data |
| spexp | Substance Painter Export Preset Data |
| spf | SQR Portable Format |
| spfs | Spider File Storage |
| spg | SG TCP Optimizer Backup |
