| sbo | SAP Business One SDK Add-on Related Data |
| sbox | sBOX Meta-file |
| sbp | OpenSBP CNC Program |
| sbq | Superbase Quick Report File |
| sbr | ScadaWorks ScadaBuilder Data |
| sbs | SpyBot Search and Destroy Include |
| sbstore | Mozilla Firefox Safebrowsing Database |
| sbw | US Treasury Savings Bonds Wizard Data |
| sc | IBM EMMS Secure Container |
| sc0 | Structure Survey Editor Profile |
| sc2 | SAS Catalog |
| sc7 | SAS Catalog |
| scad | OpenSCAD Script |
| sccef | StreamCryptor Chunked Encrypted Dat |
| sccm | System Center Configuration Manager file |
| sccs | SCCS Data |
| scd | Intuit TurboTax Tax Line Items |
| scdata | RSSIM Scene Reflectance Data |
| sce | YASARA Scene |
| scel | Sogou Pinyin Cell Dictionary Data |
| scenario | Yarn Data |
| scene | VCollab Pro Scene Data |
| scexcludb | Spring Cleaning Exclusions Data |
| sch | Microsoft SQL Server Data Replication Schema |
| sch | TINA Schematic Data |
| schakal | SCHAKAL Chemical Modeller Input file |
| schd | Microsoft Email Schedule Data |
| schdoc | Altium Designer Schematic File |
| schemas | GNOME GConf Schema Definition |
| schk | SortSite Site Data |
