| en2 | Articulate Engage Compressed Data |
| enb | EverNote Database |
| enbx | EduNetworkBuilder Network Data |
| enc | Uuencoded Data |
| enc1 | Kaspersky Anti-virus Log |
| encr | TI bqEASY Data Flash RAW |
| encrypted | HandyBits EasyCrypto Encrypted Data |
| end | Tinker End File |
| ene | GROMACS Binary Energy File |
| enex | EverNote XML Archive |
| enf | EndNote Filter Data |
| enff | Extended Neutral File Format Data |
| enfpack | Enfocus PitStop Package |
| engd | ANSYS ENGD Data |
| enh | CRiSP Harvest Model Enhancement File |
| enk | Sybase Enterprise Portal Security Key |
| enl | EndNote Library Data |
| enlx | EndNote X Compressed Library Data |
| enm | eNewsletter Manager Message Data |
| eno | FruitfulTime TaskManager Encrpted Notes |
| enp | EndNote Preferences |
| enq | EndNote Saved Search |
| enr | EnRoute v2 Toolpath Data |
| enref | EverNote Food Data |
| ens | EndNote Style |
| ens | eSignal NewsManager Preview Data |
| ent | eSignal NewsManager Data |
| ent | Protein Data Bank |
| enth | eXtendable Wad Editor ENTH Data |
| enu | ATI Radeon Video Driver Data |