| emn | Pro/ENGINEER ECAD IDF File |
| emo | Miranda IM Emotions |
| emodel | Delcam PowerSHAPE-E Model |
| emrg | E-Prime E-Merge 1.x File |
| emrg2 | E-Prime E-Merge 2.x File |
| ems | eMachineShop Data |
| emsg | SendSafe Saved E-message Data |
| emu | EMU Speech Database |
| emu | IRMA 3270 Emulation Setup Data |
| emulecollection | eMule Data |
| en2 | Articulate Engage Compressed Data |
| enb | EverNote Database |
| enbx | EduNetworkBuilder Network Data |
| enc | Uuencoded Data |
| enc1 | Kaspersky Anti-virus Log |
| encr | TI bqEASY Data Flash RAW |
| encrypted | HandyBits EasyCrypto Encrypted Data |
| end | Tinker End File |
| ene | GROMACS Binary Energy File |
| enex | EverNote XML Archive |
| enf | EndNote Filter Data |
| enff | Extended Neutral File Format Data |
| enfpack | Enfocus PitStop Package |
| engd | ANSYS ENGD Data |
| enh | CRiSP Harvest Model Enhancement File |
| enk | Sybase Enterprise Portal Security Key |
| enl | EndNote Library Data |
| enlx | EndNote X Compressed Library Data |
| enm | eNewsletter Manager Message Data |
| eno | FruitfulTime TaskManager Encrpted Notes |
