| sll | SpectraLayers Pro Layout Settings |
| smartftp | SmartFTP Configuration Data |
| smn | SetEdit Menu Configuration |
| smprf | System Mechanic Windows Startup Profile |
| smr | Smedge2 Job Settings |
| snagprof | SnagIt Profile Data |
| sno | Starry Night Pro Presets |
| sob | OpenOffice.org Configuration File |
| soc | OpenOffice.org Configuration File |
| sod | OpenOffice.org Configuration File |
| soe | OpenOffice.org Configuration File |
| sog | OpenOffice.org Configuration File |
| soh | OpenOffice.org Configuration File |
| spds | SAS Scalable Performance Data Server Configuration |
| spfx | Squeeze Presets |
| spm | Spektrum DX8 Transmitter Settings File |
| srp | Check Point Exported VPN Profile |
| srv | BNBSURVEY Configuration |
| srv | Novell Print Server Data |
| sscs | Saropa Smart Copy Script |
| ssh | OpenSSH Configuration Data |
| ssh2 | OpenSSH Client Configuration Data |
| ssis | ProReveal Test Settings File |
| ssl | Sunlite ScanLibrary |
| ssl2 | Sunlite ScanLibrary 2 |
| sso | ChessDB Saved Search Options |
| sss | Ghost Installer Silent Settings Data |
| ssu | Windows SteadyState User Profile |
| stf | ALEID2000 Settings Data |
| stf | Microsoft Setup Table File |